Selected Publications:

Olena Zhulyn, Hannah D. Rosenblatt, Leila Shokat, Shizhong Dai, Duygu Kuzuoglu-Öztürk, Zijian Zhang, Davide Ruggero, Kevan M. Shokat, Maria Barna Evolutionarily divergent mTOR remodels the translatome for tissue regeneration. Nature, 2023 in press.

Xu AF, Molinuevo R, Fazzari E, Tom H, Zhang Z, Menendez J, Casey KM, Ruggero D, Hinck L, Pritchard JK, Barna M. Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. Elife. 2023 Jun 12;12:e78695.

Liu YL, Shibuya A, Glader B, Wilkes MC, Barna M, Sakamoto KM. Animal models of Diamond-Blackfan anemia: updates and challenges. Haematologica. 2023 May 1;108(5):1222-1231.

Forester CM, Oses-Prieto JA, Phillips NJ, Miglani S, Pang X, Byeon GW, DeMarco R, Burlingame A, Barna M, Ruggero D. Regulation of eIF4E guides a unique translational program to control erythroid maturation. Science Advances. 2022 Dec 23;8(51):eadd3942.

Genuth NR, Barna M. Ribosome specialization in glioblastoma. Nature Cell Biology. 2022 Oct;24(10):1451-1453.

Genuth NR, Shi Z, Kunimoto K, Hung V, Xu AF, Kerr CH, Tiu GC, Oses-Prieto JA, Salomon-Shulman REA, Axelrod JD, Burlingame AL, Loh KM, Barna M. A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production. Nature Communications. 2022 Sep 19;13(1):5491.

Raj N, Wang M, Seoane JA, Zhao RL, Kaiser AM, Moonie NA, Demeter J, Boutelle AM, Kerr CH, Mulligan AS, Moffatt C, Zeng SX, Lu H, Barna M, Curtis C, Chang HY, Jackson PK, Attardi LD. The Mettl3 epitranscriptomic writer amplifies p53 stress responses. Molecular Cell 2022 Jul 7;82(13):2370-2384.

Barna M, Karbstein K, Tollervey D, Ruggero D, Brar G, Greer EL, Dinman JD. The promises and pitfalls of specialized ribosomes. Molecular Cell. 2022 Jun 16;82(12):2179-2184.

Leppek K*, Byeon GW,* Kladwang W*, Wayment-Steele HK*, Kerr CH*, Xu AF, Kim DS, Topkar VV, Choe C, Rothschild D, Tiu GC, Wellington-Oguri R, Fujii K, Sharma E, Watkins AM, Nicol JJ, Romano J, Tunguz B, Diaz F, Cai H, Guo P, Wu J, Meng F, Shi S, Participants E, Dormitzer PR, Solórzano A, Barna M#, Das R#. Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics. Nature Communications. 2022 Mar 22;13(1):1536.
*Co-First Author
#Co-Senior Author

Fujii K, Zhulyn O, Byeon GW, Genuth NR, Kerr CH, Walsh EM, Barna M. Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Developmental Cell. 2021 Nov 8;56(21):2928-2937.e9.
Preview Article: Giving Translation a hand. Developmental Cell November 2021

Tiu, G. C*., Kerr, C. H.*, Forester, C. M., Krishnarao, P. S., Rosenblatt, H. D., Raj, N., Zhulyn, O., Bowen, M. E., Shokat, L., Attardi, L. D., Ruggero, D. & Barna, M. A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies. Developmental Cell, 2021 July 3; S1543-5807(21)00520-7.
*Co-First Author

Zhang Z, Denans N, Liu Y, Zhulyn O, Rosenblatt HD, Wernig M, Barna M. Optogenetic manipulation of cellular communication using engineered myosin motors. Nature Cell Biology, 2021 Feb;23(2):198-208.
Preview Article: Engineered myosins drive filopodial transport. Nature Cell Biology February 2021

Byen, G. W., Cenik, E. S., Jiang, L., Tang, H., Das, R. & Barna, M. Functional and structural basis of extreme non-coding conservation in vertebrate mRNA 5’ untranslated regions. Nature Genetics, 2021 May; 53(5) 729–741.
Preview Article:Extreme conservation encodes the structural dynamics and function of 5′ UTRs. Nature Genetics May 2021

Leppek K*, Byeon GW*, Fujii K, Barna M. VELCRO-IP RNA-seq reveals ribosome expansion segment function in translation genome-wide. Cell Reports, 2021 Jan 19;34(3):108629.
*Co-First Author

Leppek K, Fujii K, Quade N, Susanto TT, Boehringer D, Lenarčič T, Xue S, Genuth NR, Ban N, Barna M. Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments. Molecular Cell, 2020 Dec 17;80(6):980-995.e13.

Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, Partridge L, Ichida JK, Isaacs AM, Petrucelli L, Gitler AD. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nature Neuroscience, 22, 1383-1388, 2019.
Xu Y*, Poggio M*, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D. Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nature Medicine, 25, 301-311, 2019.
*These authors contributed equally to this work.
Fujii K, Susanto T, Saurabh S, & Barna M. Decoding the Function of Expansion Segments in Ribosomes. Molecular Cell, 72, 1013-1020, 2018.
Genuth R & Barna M. The discovery of ribosome heterogeneity and its implications for gene regulation and organismal life. Molecular Cell, 71 (3), 364–374, 2018. Special 25th Anniversary Issue of Molecular Cell: “Shaping Molecular Biology”
Leppek K, Das R, Barna M. Functional 5'UTR mRNA structures in eukaryotic translation and how to find them. Nature Reviews Molecular Cellular Biology, 19, 158–174, 2018.
Genuth R & Barna M. Heterogeneity and specialized functions of translation machinery: from genes to organisms. Nature Reviews Genetics, 19, 431–452, 2018.
Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, Chang HY, Barna M. The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell, 169 (6): 1051–65, 2017.
Research Highlights: A division of labor in cells’ protein factories. Science 2017, June 23; RAPing with ribosomes. Nature Reviews Molecular and Cell Biology 2017, June14; Principles of Systems Biology: A ribosome RAPsody. Cell Systems 2017, June 28; Ribosomes are functionally diverse. The Scientist 2017, June 22
Shi Z, Fujii K, Kovary KM, Genuth NR, Roost HL, Teruel MN, & Barna M. Heterogeneous ribosomes selectively translate distinct subpools of mRNAs genome-wide. Molecular Cell, 67, 71-83, 2017.
Research Highlights: A division of labor in cells’ protein factories. Science 2017, June 23; Ribosomes are functionally diverse. The Scientist 2017, June 2; Subtraction Heterogeneity: A critical step toward defining specialized ribosomes. Molecular Cell 2017, July 6
Fujii K*, Shi Z*, Zhulyn O*, Denans N, & Barna M. Pervasive translational regulation of the cell signaling circuitry underlies mammalian development. Nature Communications, 8:1443, 2017.
*These authors contributed equally to this work.
Simsek D, & Barna M. An emerging role for the ribosome as a nexus for post-translational modifications. Current Opinion in Cell Biology 45: 92–101, 2017.
Shi Z & Barna M. Translating the Genome in Time and Space. Annual Review Cell Dev Biol, 13(31):31-54, 2015.
Xue S & Barna M. Cis-regulatory RNA elements that regulate specialized ribosome activity. RNA Biology, 12(10):1083-7, 2015
Truitt M^, Conn CS^, Shi Z, Pang X, Tokuyasu T, Coady A, Seo Y, Barna M* & Ruggero D*.
Differential requirements for eIF4E dose in normal development and cancer. Cell, 162(1):59-71, 2015. *Co-Senior and Co-Corresponding Author; ^Co-First Author
Xue S, Tian S, Fujii K, Kladwang K, Das R, & Barna M. RNA regulons in Hox 5’UTRs confer ribosome specificity to gene regulation and body plan formation. Nature (Article), 517(7532):33-8, 2015.
Preview Article: Molecular Biology: Entry Signals Control Development. Nature 2014 Nov 19.; Feature: Faculty of 1000 received a 3.0 (“Exceptional”)
Sanders TA*, Llagostera E*, & Barna M. Specialized filopodia direct long-range transport of Shh during vertebrate tissue patterning. Nature, 497:628-32, 2013.
*These authors contributed equally to this work
Preview Article: Filopodia: The Cellular Quills of Hedgehog Signaling? Developmental Cell 25:328-330, 2013; Preview Article: Cytonemes extend their reach. EMBO 2013 May 14; Faculty of 1000; received a 7.0 (“Must Read”)
Xue S & Barna M. Specialized ribosomes: a new frontier in gene regulation and organismal biology. Nature Reviews Molecular and Cellular Biology, 13: 355-69, 2012.
Kondrashov N, Pusic A*, Stumpf CR*, Shimizu K, Hsieh AC, Xue S, Ishijima J, Shiroishi T & Barna M. Ribosome mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell 145: 383-397, 2011.
* These authors contributed equally to this work.
Preview Article: Topisirovic T & Sonenberg N. Translational Control by the Eukaryotic Ribosome. Cell 145: 333-334, 2011; Research Highlight: Protein maker and gene regulator. Nature 473:127, 2011; Research Highlight: Gene Expression: Personalized Ribosomes. Nature Reviews Molecular Cell Biology 12:344-345, 2011; Research Highlight: Nature Reviews Genetics 12:382, 2011; Feature: Editors Choice in Cell Biology: Ribosomes in Control. The Scientist September 2011; Feature: Faculty of 1000: received a 20.0 (top 2% of all evaluated articles); Cell biology 2011: Signaling breakthroughs of the year. Science Signaling 5: p. eg 1, 2012.
Barna M*, Pusic A^, Zollo O^, Costa M, Kondrashov N, Rego E, Rao PH, Ruggero D*. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 456: 971-975, 2008. ^ These authors contributed equally to this work.*Co-Corresponding Author
Research Highlight: Nature Reviews Cancer 9:4-5, 2009; Feature: Faculty of 1000; received a 10.0 (“Exceptional”)
Barna M*, Niswander L*. Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. Developmental Cell 12: 931-41, 2007.
*Co-Corresponding Author